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Article

High throughput detection of microsatellite instability by denaturing high-performance liquid chromatography.

Human mutation - 1 Nov 2003

Pan Kai-feng, Liu Wanguo, Lu You-Yong, Zhang Lian, Li Zhen-pu, Lu Wan-Li, Thibodeau Stephen N, You Wei-Cheng

Abstract excerpt

Microsatellite instability (MSI) is a hallmark of the DNA replication error phenotype, due to the inactivation of mismatch repair genes. MSI has been implicated in colon and many other gastrointestinal cancers. MSI usually can be analyzed by PCR amplification of microsatellite markers followed by electrophoresis and detected using autoradiography or fluorescence techniques. We report here a novel method for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14517950
DOI: 10.1002/humu.10271

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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