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Article

E2F7 Is a Potent Inhibitor of Liver Tumor Growth in Adult Mice

7 Apr 2020

Abstract excerpt

BACKGROUND AND AIMS: Up-regulation of the E2F-dependent transcriptional network has been identified in nearly every human malignancy and is an important driver of tumorigenesis. Two members of the E2F family, E2F7 and E2F8, are potent repressors of E2F-dependent transcription. They are atypical in that they do not bind to dimerization partner proteins and are not controlled by retinoblastoma protein. The...

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PMID: 32259305
DOI: 10.1002/hep.31259

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