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Article

Myc-induced liver tumors in transgenic zebrafish can regress in tp53 null mutation.

PloS one - 1 Jan 2015

Sun Lili, Nguyen Anh Tuan, Spitsbergen Jan M, Gong Zhiyuan

Abstract excerpt

Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing trend. Deregulation of MYC in HCC is frequently detected and always correlated with poor prognosis. As the zebrafish genome contains two differentially expressed zebrafish myc orthologs, myca and mycb, it remains unclear about the oncogenicity of the two zebrafish myc genes. In the present study, we developed two...

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Share to Animals, Genetically Modified
Share to Carcinoma, Hepatocellular
Share to Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-myc

Share to Tumor Suppressor Protein p53

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Source

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Identifiers

PMID: 25612309
DOI: 10.1371/journal.pone.0117249
PMCID: PMC4303426

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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