Article
Hormone-response genes are direct in vivo regulatory targets of Brahma (SWI/SNF) complex function.
The Journal of biological chemistry - 17 Nov 2006
Zraly Claudia B, Middleton Frank A, Dingwall Andrew K
Abstract excerpt
Metazoan SWI/SNF chromatin remodeling complexes exhibit ATP-dependent activation and repression of target genes. The Drosophila Brahma (SWI/SNF) complex subunits BRM and SNR1 are highly conserved with direct counterparts in yeast (SWI2/SNF2 and SNF5) and mammals (BRG1/hBRM and INI1/hSNF5). BRM encodes the catalytic ATPase required for chromatin remodeling and SNR1 is a regulatory subunit. Importantly, SNR1...
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