Article
lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal.
Cell - 7 Aug 1998
Meno C, Shimono A, Saijoh Y, Yashiro K, Mochida K, Ohishi S, Noji S, Kondoh H, Hamada H
Abstract excerpt
lefty-1, lefty-2, and nodal are expressed on the left side of developing mouse embryos and are implicated in left-right (L-R) determination. The role of lefty-1 was examined by analyzing mutant mice lacking this gene. The lefty-1-deficient mice showed a variety of L-R positional defects in viscer...
Topics
- Animals
- Animals, Newborn
- Body Patterning
- Gene Expression Regulation, Developmental
- Homeodomain Proteins
- Left-Right Determination Factors
- Lung
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Mutation
- Nodal Protein
- Nuclear Proteins
- Paired Box Transcription Factors
- Proteins
- Transcription Factors