Article
Pathogenesis of persistent hyperplastic primary vitreous in mice lacking the arf tumor suppressor gene.
Investigative ophthalmology & visual science - 1 Oct 2004
Martin Amy C, Thornton J Derek, Liu Jiewiu, Wang XiaoFei, Zuo Jian, Jablonski Monica M, Chaum Edward, Zindy Frederique, Skapek Stephen X
Abstract excerpt
PURPOSE: Persistent hyperplastic primary vitreous (PHPV) is an idiopathic developmental eye disease associated with failed involution of the hyaloid vasculature. The present work addressed the pathogenesis of PHPV in a mouse model that replicates many aspects of the human disease. METHODS: Ophthalmoscopic and histologic analyses documented pathologic processes in eyes of mice lacking the Arf gene compared with...
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