Article
Varied manifestations of persistent hyperplastic primary vitreous with graded somatic mosaic deletion of a single gene.
Molecular vision - 1 Jan 2014
Mary-Sinclair Michelle N, Wang Xiaofei, Swanson Douglas J, Sung Caroline Y, Mendonca Eneida A, Wroblewski Kristen, Baumer Shannon H, Goldowitz Dan, Jablonski Monica M, Skapek Stephen X
Abstract excerpt
PURPOSE: Persistent hyperplastic primary vitreous (PHPV) represents a developmental eye disease known to have diverse manifestations ranging from a trivial remnant of hyaloid vessels to a dense fibrovascular mass causing lens opacity and retinal detachment. PHPV can be modeled in mice lacking individual genes, but certain features of such models differ from the clinical realm. For example, mice lacking the Arf...
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