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Article

Transgenic expression of a mutant glycine receptor decreases alcohol sensitivity of mice.

The Journal of pharmacology and experimental therapeutics - 1 Feb 2002

Findlay G S, Wick M J, Mascia M P, Wallace D, Miller G W, Harris R A, Blednov Y A

Abstract excerpt

Glycine receptors (GlyRs) are pentameric ligand-gated ion channels that inhibit neurotransmission in the adult brainstem and spinal cord. GlyR function is potentiated by ethanol in vitro, and a mutant GlyR subunit alpha(1)(S267Q) is insensitive to the potentiating effects of ethanol. To test the importance of GlyR for the actions of ethanol in vivo, we constructed transgenic mice with this mutation. Under the...

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Source

Identifiers

PMID: 11805213
DOI: 10.1124/jpet.300.2.526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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