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Suppression of chemically induced and spontaneously occurring oxidative mutagenesis by three alleles of human OGG1 gene encoding 8-hydroxyguanine DNA glycosylase.

Mutation research - 4 Oct 2004

Kim Su-Ryang, Matsui Keiko, Yamada Masami, Kohno Takashi, Kasai Hiroshi, Yokota Jun, Nohmi Takehiko

Abstract excerpt

8-Hydroxyguanine (8-OH-G) is an oxidatively damaged guanine base that causes G:C to T:A transversion mutations. To counteract the mutagenicity of 8-OH-G in DNA, humans possess the hOGG1 gene, which encodes 8-OH-G DNA glycosylase. Interestingly, genetic polymorphisms at codon 326 (hOGG1-Ser326 versus hOGG1-Cys326) and at codon 46 (hOGG1-Arg46 versus hOGG1-Gln46) exist in human populations. hOGG1-Ser326 and -Cys326...

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Identifiers

PMID: 15450432
DOI: 10.1016/j.mrfmmm.2004.05.013

Genes

OGG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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