Article
Fluid shear stress induction of the tissue factor promoter in vitro and in vivo is mediated by Egr-1.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 1999
Houston P, Dickson M C, Ludbrook V, White B, Schwachtgen J L, McVey J H, Mackman N, Reese J M, Gorman D G, Campbell C, Braddock M
Abstract excerpt
Hemodynamic forces such as fluid shear stress have been shown to modulate the activity of an expanding family of genes involved in vessel wall homeostasis and the pathogenesis of vascular disease. We have investigated the effect of shear stress on tissue factor (TF) gene expression in human endothelial cells (ECs) and in a rat arterial model of occlusion. As measured by reverse transcriptase polymerase chain...
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