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Article

Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe.

Molecular and cellular biology - 1 Jun 1996

Degols G, Shiozaki K, Russell P

Abstract excerpt

Spc1, an osmotic-stress-stimulated mitogen-activated protein kinase (MAPK) homolog in the fission yeast Schizosaccharomyces pombe, is required for the induction of mitosis and survival in high-osmolarity conditions. Spc1, also known as Sty1, is activated by Wis1 MAPK kinase and inhibited by Pyp1 tyrosine phosphatase. Spc1 is most closely related to Saccharomyces cerevisiae Hog1 and mammalian p38 kinases. Whereas...

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Identifiers

PMID: 8649397
DOI: 10.1128/MCB.16.6.2870
PMCID: PMC231280

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Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe.PMID 8649397Read ↗

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