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Article

Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.

The Journal of biological chemistry - 3 Dec 2004

Joseph Jamie W, Koshkin Vasilij, Saleh Monique C, Sivitz William I, Zhang Chen-Yu, Lowell Bradford B, Chan Catherine B, Wheeler Michael B

Abstract excerpt

Chronic exposure to elevated free fatty acids (lipotoxicity) induces uncoupling protein (UCP2) in the pancreatic beta-cell, and therefore a causal link between UCP2 and beta-cell defects associated with obesity may exist. Recently, we showed that lipid treatment in vivo and in vitro in UCP2(-/-) mice/islets does not result in any loss in beta-cell glucose sensitivity. We have now assessed the mechanism of...

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Source

Identifiers

PMID: 15448158
DOI: 10.1074/jbc.M409189200

Genes

UCP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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