Article
Elimination of KATP channels in mouse islets results in elevated [U-13C]glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased gamma-aminobutyric acid shunt.
The Journal of biological chemistry - 20 Jun 2008
Li Changhong, Nissim Itzhak, Chen Pan, Buettger Carol, Najafi Habiba, Daikhin Yevgeny, Nissim Ilana, Collins Heather W, Yudkoff Marc, Stanley Charles A, Matschinsky Franz M
Abstract excerpt
Pancreatic beta cells are hyper-responsive to amino acids but have decreased glucose sensitivity after deletion of the sulfonylurea receptor 1 (SUR1) both in man and mouse. It was hypothesized that these defects are the consequence of impaired integration of amino acid, glucose, and energy metabo...
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