Article
Impaired noradrenaline-induced lipolysis in white fat of aP2-Ucp1 transgenic mice is associated with changes in G-protein levels.
The Biochemical journal - 1 Jun 2002
Flachs Pavel, Novotný Jirí, Baumruk Filip, Bardová Kristina, Bourová Lenka, Miksík Ivan, Sponarová Jana, Svoboda Petr, Kopecký Jan
Abstract excerpt
In vitro experiments suggest that stimulation of lipolysis by catecholamines in adipocytes depends on the energy status of these cells. We tested whether mitochondrial uncoupling proteins (UCPs) that control the efficiency of ATP production could affect lipolysis and noradrenaline signalling in white fat in vivo. The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1...
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