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Article

Prereplicative purine methylation and postreplicative demethylation in each DNA duplication of the Escherichia coli replication cycle.

The Journal of biological chemistry - 3 Dec 2004

Maas Renata

Abstract excerpt

Escherichia coli plasmid DNA activated for initiation of duplication is in a stable low linking number supercoiled conformation. Low linking number DNA is methylated at the internal purines of a frequent 5'-Pyr-Pyr-Pur-Pur tetramer with a 5'-Pyr-Pur-3' axis of symmetry and is cut at the axis of symmetry by pneumococcal restriction enzyme DpnI when methylated in both strands. Purine methylation is of adenine in...

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PMID: 15448156
DOI: 10.1074/jbc.M407394200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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