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Article

Mechanism of DNA binding and localized strand separation by Pur alpha and comparison with Pur family member, Pur beta.

Biochimica et biophysica acta - 22 Mar 2005

Wortman Margaret J, Johnson Edward M, Bergemann Andrew D

Abstract excerpt

Pur alpha is a single-stranded (ss) DNA- and RNA-binding protein with three conserved signature repeats that have a specific affinity for guanosine-rich motifs. Pur alpha unwinds a double-stranded oligonucleotide containing purine-rich repeats by maintaining contact with the purine-rich strand and displacing the pyrimidine-rich strand. Mutational analysis indicates that arginine and aromatic residues in the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15777841
DOI: 10.1016/j.bbamcr.2004.08.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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