Article
The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin alpha4beta7.
The Journal of biological chemistry - 31 Dec 2004
Chen JianFeng, Takagi Junichi, Xie Can, Xiao Tsan, Luo Bing-Hao, Springer Timothy A
Abstract excerpt
We examined the effect of conformational change at the beta(7) I-like/hybrid domain interface on regulating the transition between rolling and firm adhesion by integrin alpha(4)beta(7). An N-glycosylation site was introduced into the I-like/hybrid domain interface to act as a wedge and to stabilize the open conformation of this interface and hence the open conformation of the alpha(4) beta(7) headpiece. Wild-type...
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