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Article

Identification, characterization, and epitope mapping of human monoclonal antibody J19 that specifically recognizes activated integrin α4β7.

The Journal of biological chemistry - 4 May 2012

Qi JunPeng, Zhang Kun, Zhang Qiao, Sun Yi, Fu Ting, Li GuoHui, Chen JianFeng

Abstract excerpt

Integrin α(4)β(7) is a lymphocyte homing receptor that mediates both rolling and firm adhesion of lymphocytes on vascular endothelium, two of the critical steps in lymphocyte migration and tissue-specific homing. The rolling and firm adhesions of lymphocytes rely on the dynamic shift between the inactive and active states of integrin α(4)β(7), which is associated with the conformational rearrangement of integrin...

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Source

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Identifiers

PMID: 22418441
DOI: 10.1074/jbc.M112.341263
PMCID: PMC3346070

Genes

CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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