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Article

The role of alpha and beta chains in ligand recognition by beta 7 integrins.

The Journal of biological chemistry - 18 Aug 2000

Higgins J M, Cernadas M, Tan K, Irie A, Wang J, Takada Y, Brenner M B

Abstract excerpt

Integrins alpha(E)beta(7) and alpha(4)beta(7) are involved in localization of leukocytes at mucosal sites. Although both alpha(E)beta(7) and alpha(4)beta(7) utilize the beta(7) chain, they have distinct binding specificities for E-cadherin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1), respectively. We found that mutation of the metal ion-dependent adhesion site (MIDAS) in the alpha(E) A-domain...

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PMID: 10837471
DOI: 10.1074/jbc.M001228200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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