Article
Regulation of integrin αIIbβ3 ligand binding and signaling by the metal ion binding sites in the β I domain.
Biochemistry - 29 Mar 2011
Raborn Joel, Wang Wei, Luo Bing-Hao
Abstract excerpt
The ability of αIIbβ3 to bind ligands and undergo outside-in signaling is regulated by three divalent cation binding sites in the β I domain. Specifically, the metal ion-dependent adhesion site (MIDAS) and the synergistic metal binding site (SyMBS) are thought to be required for ligand binding du...
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