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Article

Variation in one residue associated with the metal ion-dependent adhesion site regulates αIIbβ3 integrin ligand binding affinity.

PloS one - 1 Jan 2013

Raborn Joel, Fu Ting, Wu Xue, Xiu Zhilong, Li Guohui, Luo Bing-Hao

Abstract excerpt

The Asp of the RGD motif of the ligand coordinates with the β I domain metal ion dependent adhesion site (MIDAS) divalent cation, emphasizing the importance of the MIDAS in ligand binding. There appears to be two distinct groups of integrins that differ in their ligand binding affinity and adhesion ability. These differences may be due to a specific residue associated with the MIDAS, particularly the β3 residue...

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Identifiers

PMID: 24116162
DOI: 10.1371/journal.pone.0076793
PMCID: PMC3792891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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