Article
Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signaling.
The Journal of biological chemistry - 3 Dec 2004
Fernández-Monreal Mónica, López-Atalaya José P, Benchenane Karim, Cacquevel Mathias, Dulin Fabienne, Le Caer Jean-Pierre, Rossier Jean, Jarrige Anne-Charlotte, Mackenzie Eric T, Colloc'h Nathalie, Ali Carine, Vivien Denis
Abstract excerpt
Tissue-type plasminogen activator (tPA) has been involved in both physiological and pathological glutamatergic-dependent processes, such as synaptic plasticity, seizure, trauma, and stroke. In a previous study, we have shown that the proteolytic activity of tPA enhances the N-methyl-D-aspartate (NMDA) receptor-mediated signaling in neurons (Nicole, O., Docagne, F., Ali, C., Margaill, I., Carmeliet, P., MacKenzie,...
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