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Article

Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice.

Blood - 16 Apr 2015

Hijazi Nuha, Abu Fanne Rami, Abramovitch Rinat, Yarovoi Serge, Higazi Muhamed, Abdeen Suhair, Basheer Maamon, Maraga Emad, Cines Douglas B, Higazi Abd Al-Roof

Abstract excerpt

Persistent intracerebral hemorrhage (ICH) is a major cause of death and disability after traumatic brain injury (TBI) for which no medical treatment is available. Delayed bleeding is often ascribed to consumptive coagulopathy initiated by exposed brain tissue factor. We examined an alternative hypothesis, namely, that marked release of tissue-type plasminogen activator (tPA) followed by delayed synthesis and...

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Source

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Identifiers

PMID: 25673638
DOI: 10.1182/blood-2014-08-588442
PMCID: PMC4400292

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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