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Article

Improvement of Psychotic Symptoms and the Role of Tissue Plasminogen Activator.

International journal of molecular sciences - 18 Nov 2015

Hoirisch-Clapauch Silvia, Nardi Antonio E

Abstract excerpt

Tissue plasminogen activator (tPA) mediates a number of processes that are pivotal for synaptogenesis and remodeling of synapses, including proteolysis of the brain extracellular matrix, degradation of adhesion molecules, activation of neurotrophins, and activation of the N-methyl-d-aspartate receptor. Abnormalities in these processes have been consistently described in psychotic disorders. In this paper, we...

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Identifiers

PMID: 26593907
DOI: 10.3390/ijms161126053
PMCID: PMC4661911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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