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Article

Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization.

The Journal of biological chemistry - 3 Dec 2004

Vooijs Marc, Schroeter Eric H, Pan Yonghua, Blandford Mary, Kopan Raphael

Abstract excerpt

Intramembrane cleaving proteases such as site 2 protease, gamma-secretase, and signal peptide peptidase hydrolyze peptide bonds within the transmembrane domain (TMD) of signaling molecules such as SREBP, Notch, and HLA-E, respectively. All three enzymes require a prior cleavage at the juxtamembrane region by another protease. It has been proposed that removing the extracellular domain allows dissociation of...

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PMID: 15448134
DOI: 10.1074/jbc.M409430200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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