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Article

Comparison of a multipoint identity-by-descent method with parametric multipoint linkage analysis for mapping quantitative traits.

American journal of human genetics - 1 Mar 1992

Goldgar D E, Oniki R S

Abstract excerpt

We previously developed a method of partitioning genetic variance of a quantitative trait to loci in specific chromosomal regions. In this paper, we compare this method--multipoint IBD (identical by descent) method (MIM)--with parametric multipoint linkage analysis (MLINK). A simulation study was performed comparing the methods for the major-locus, mixed, and two-locus models. The criterion for comparisons...

Topics

Chromosome Mapping
Computer Simulation
Confounding Factors, Epidemiologic
Gene Frequency
Genes, Dominant
Genetic Linkage
Genetic Markers
Genetic Variation
Humans
Likelihood Functions
Lod Score

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Genetic

Parents

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Identifiers

PMID: 1539596
PMCID: PMC1684304

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1539596-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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