Article
Multipoint identity-by-descent prediction using dense markers to map quantitative trait loci and estimate effective population size.
Genetics - 1 Aug 2007
Meuwissen Theo H E, Goddard Mike E
Abstract excerpt
A novel multipoint method, based on an approximate coalescence approach, to analyze multiple linked markers is presented. Unlike other approximate coalescence methods, it considers all markers simultaneously but only two haplotypes at a time. We demonstrate the use of this method for linkage disequilibrium (LD) mapping of QTL and estimation of effective population size. The method estimates identity-by-descent...
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