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Article

Sample-size guidelines for linkage analysis of a dominant locus for a quantitative trait by the method of lod scores.

American journal of human genetics - 1 Aug 1990

Boehnke M

Abstract excerpt

Sample-size guidelines for linkage studies of quantitative traits partially determined by a dominant major locus are needed to provide a rough estimate of the amount of pedigree material that should be sampled to map the loci that influence such traits. After pedigrees are sampled, a specific power calculation can be carried out to evaluate the linkage information provided by the sampled pedigrees. Using computer...

Topics

Female
Genes, Dominant
Genetic Linkage
Genetic Variation
Humans
Lod Score
Male
Models, Genetic
Sampling Studies

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2378347
PMCID: PMC1683715

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2378347-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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