Heterogeneity analysis of breast cancer families by using age at onset as a covariate.

Article

Heterogeneity analysis of breast cancer families by using age at onset as a covariate.

American journal of human genetics - 1 Mar 1992

Mérette C, King M C, Ott J

Abstract excerpt

An extension of the usual mixture model of heterogeneity (two family types, one with and one without linkage) is proposed by introducing age at onset as a covariate. The extended model defines age-dependent penetrances where the exact parametrization of age-at-onset distributions depends on the g...

Topics

Adult
Age Factors
Aged
Breast Neoplasms
Chi-Square Distribution
Cluster Analysis
Female
Gene Expression
Genetic Linkage
Genetic Variation
Humans
Likelihood Functions
Middle Aged
Models, Genetic
Polymorphism, Genetic
Recombination, Genetic
Risk Factors
United States

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