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Article

Segregation analysis of breast cancer: a comparison of type-dependent age-at-onset versus type-dependent susceptibility models.

Genetic epidemiology - 1 Jan 1996

Ciske D J, Rich S S, King R A, Anderson V E, Bartow S, Vachon C, McGovern P G, Kushi L H, Zheng W, Sellers T A

Abstract excerpt

Most segregation analyses of breast cancer susceptibility have modeled the effect of the major gene on the age-at-onset distribution. However, in families linked to BRCA1 or BRCA2, there is wide variation in the age-at-onset among gene carriers. We performed a segregation analysis of 544 Minnesota breast cancer families using models which parameterized the putative major gene effect in two ways: earlier...

Topics

Adult
Age of Onset
Aged
Aged, 80 and over
Breast Neoplasms
Female
Genetic Heterogeneity
Genetic Predisposition to Disease
Humans
Middle Aged
Models, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8894635
DOI: 10.1002/(SICI)1098-2272(1996)13:4<317::AID-GEPI1>3.0.CO;2-1

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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