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Article

Synaptic transmission and synchronous activity is disrupted in hippocampal slices taken from aged TAS10 mice.

Hippocampus - 1 Jan 2005

Brown Jon T, Richardson Jill C, Collingridge Graham L, Randall Andrew D, Davies Ceri H

Abstract excerpt

Synaptic transmission was studied in hippocampal slices from aged (12-14 months of age) TAS10 mice overexpressing the human form of the amyloid precursor protein harboring the Swedish mutation. A significant deficit in the input-output relationship of glutamatergic synapses in the CA3-CA1 Schaffer collateral pathway was observed, while synaptic transmission in the medial perforant pathway of the dentate gyrus was...

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Identifiers

PMID: 15390159
DOI: 10.1002/hipo.20036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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