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Article

Effect of tumor-associated mutant E-cadherin variants with defects in exons 8 or 9 on matrix metalloproteinase 3.

Journal of cellular physiology - 1 Mar 2005

Fuchs Margit, Hermannstädter Christine, Specht Katja, Knyazev Pjotr, Ullrich Axel, Rosivatz Erika, Busch Raymonde, Hutzler Peter, Höfler Heinz, Luber Birgit

Abstract excerpt

Tumor progression is characterized by loss of cell adhesion and increase of invasion and metastasis. The cell adhesion molecule E-cadherin is frequently down-regulated or mutated in tumors. In addition to down-regulation of cell adhesion, degradation of the extracellular matrix by matrix metalloproteinases is necessary for tumor cell spread. To investigate a possible link between E-cadherin and matrix...

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PMID: 15389640
DOI: 10.1002/jcp.20192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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