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Article

Influence of tumor-associated E-cadherin mutations on tumorigenicity and metastasis.

Carcinogenesis - 1 Dec 2003

Kremer Marcus, Quintanilla-Martinez Leticia, Fuchs Margit, Gamboa-Dominguez Armando, Haye Sieglinde, Kalthoff Holger, Rosivatz Erika, Hermannstädter Christine, Busch Raymonde, Höfler Heinz, Luber Birgit

Abstract excerpt

In this study, we investigated whether tumor-associated E-cadherin mutations impair the tumor-suppressive function of the cell adhesion molecule and influence metastasis formation in a severe combined immunodeficiency mouse model. The investigated E-cadherin mutations were in frame deletions of exons 8 (del 8) or 9 (del 9) and a point mutation in exon 8 (p8). Transfected human MDA-MB-435S carcinoma cells stably...

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PMID: 12949051
DOI: 10.1093/carcin/bgg148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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