Article
Down-regulation of E-cadherin in mouse skin carcinoma cells enhances a migratory and invasive phenotype linked to matrix metalloproteinase-9 gelatinase expression.
Laboratory investigation; a journal of technical methods and pathology - 1 Sept 1998
Llorens A, Rodrigo I, López-Barcons L, Gonzalez-Garrigues M, Lozano E, Vinyals A, Quintanilla M, Cano A, Fabra A
Abstract excerpt
To assess the role of gelatinases in mouse skin tumor progression and their link to the expression of E-cadherin (E-CD), the cell-cell adhesion protein, we used the highly metastatic squamous HaCa4 cell line and several HaCa4-derived clones obtained by transfection of the mouse E-CD cDNA. Express...
Topics
- Animals
- Antisense Elements (Genetics)
- Cadherins
- Carcinoma, Squamous Cell
- Cell Count
- Cell Movement
- Collagenases
- DNA, Complementary
- Epidermis
- Lung Neoplasms
- Male
- Matrix Metalloproteinase 9
- Mice
- Mice, Inbred BALB C