Article
Specific blockade of the ERK pathway inhibits the invasiveness of tumor cells: down-regulation of matrix metalloproteinase-3/-9/-14 and CD44.
Biochemical and biophysical research communications - 16 May 2003
Tanimura Susumu, Asato Keita, Fujishiro Shuh-hei, Kohno Michiaki
Abstract excerpt
Elevated expression of matrix metalloproteinases (MMPs) is associated with increased metastatic potential in many tumor cells. As activation of the ERK pathway has been linked to the expression of MMP-9, we examined a possible correlation between ERK activation, MMP-9 expression, and invasive phenotype in human tumor cells. Activation state of the ERK pathway in tumor cells was well correlated with the invasive...
Topics
- Benzamides
- Down-Regulation
- Enzyme Activation
- Enzyme Inhibitors
- Humans
- Hyaluronan Receptors
- MAP Kinase Signaling System
- Matrix Metalloproteinase 3
- Matrix Metalloproteinase 9
- Matrix Metalloproteinases, Membrane-Associated
- Metalloendopeptidases
- Mitogen-Activated Protein Kinases
- Neoplasm Invasiveness