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Article

Insulin-like growth factor binding protein-3 inhibits migration of endometrial cancer cells.

Cancer letters - 1 Apr 2012

Gribben Lujia, Baxter Robert C, Marsh Deborah J

Abstract excerpt

Cell migration and invasion leading to metastasis is a major cause of death from endometrial cancer (EC). We have shown that the rate of EC cell migration is inversely related to the level of insulin-like growth factor protein-3 (IGFBP-3). Down-regulation of IGFBP-3 by siRNA in EC cells accelerated migration without affecting proliferation and cells displayed a more migratory phenotype, with co-localization of...

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PMID: 22085490
DOI: 10.1016/j.canlet.2011.11.011

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PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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