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Article

Dislocation of a type I membrane protein requires interactions between membrane-spanning segments within the lipid bilayer.

Molecular biology of the cell - 1 Sept 2003

Lilley Brendan N, Tortorella Domenico, Ploegh Hidde L

Abstract excerpt

The human cytomegalovirus gene product US11 causes rapid degradation of class I major histocompatibility complex (MHCI) heavy chains by inducing their dislocation from the endoplasmic reticulum (ER) and subsequent degradation by the proteasome. This set of reactions resembles the endogenous cellular quality control pathway that removes misfolded or unassembled proteins from the ER. We show that the transmembrane...

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Identifiers

PMID: 12972557
DOI: 10.1091/mbc.e03-03-0192
PMCID: PMC196560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Dislocation of a type I membrane protein requires interactions between membrane-spanning segments within the lipid bilayer.PMID 12972557Read ↗

The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate.Semantic proximity Read ↗

Ubiquitination is essential for human cytomegalovirus US11-mediated dislocation of MHC class I molecules from the endoplasmic reticulum to the cytosol.Semantic proximity Read ↗

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the CytosolSemantic proximity Read ↗

Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradation.Semantic proximity Read ↗

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER.Semantic proximity Read ↗

Disease-related misassembly of membrane proteins.Semantic proximity Read ↗

Binding of human cytomegalovirus US2 to major histocompatibility complex class I and II proteins is not sufficient for their degradation.Semantic proximity Read ↗

The HCMV gene products US11 and US2 differ in their ability to attack allelic forms of murine major histocompatibility complex (MHC) class I heavy chains.Semantic proximity Read ↗

Amino acid composition of α1/α2 domains and cytoplasmic tail of MHC class I molecules determine their susceptibility to human cytomegalovirus US11‐mediated down‐regulationSemantic proximity Read ↗

Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation.Semantic proximity Read ↗

HCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling pathwaysSemantic proximity Read ↗

Subtle sequence variation among MHC class I locus products greatly influences sensitivity to HCMV US2- and US11-mediated degradation.Semantic proximity Read ↗

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