Article
Genetic background of celiac disease and its clinical implications.
The American journal of gastroenterology - 1 Jan 2008
Wolters Victorien M, Wijmenga Cisca
Abstract excerpt
Celiac disease (CD) is a complex genetic disorder with multiple contributing genes. Linkage studies have identified several genomic regions that probably contain CD susceptibility genes. The most important genetic factors identified are HLA-DQ2 and HLA-DQ8, which are necessary but not sufficient to predispose to CD. The associations found in non-HLA genomewide linkage and association studies are much weaker. This...
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