Article
Dietary folate intake and k-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study.
International journal of cancer - 1 May 2005
Brink Mirian, Weijenberg Matty P, de Goeij Anton F P M, Roemen Guido M J M, Lentjes Marjolein H F M, de Bruïne Adriaan P, van Engeland Manon, Goldbohm R Alexandra, van den Brandt Piet A
Abstract excerpt
We studied the association between dietary folate and specific K-ras mutations in colon and rectal cancer in The Netherlands Cohort Study on diet and cancer. After 7.3 years of follow-up, 448 colon and 160 rectal cancer patients and 3,048 sub-cohort members (55-69 years at baseline) were available for data analyses. Mutation analysis of the K-ras gene was carried out on all archival adenocarcinoma specimens....
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