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Acetylation Regulates WRN Catalytic Activities and Affects Base Excision DNA Repair

8 Apr 2008

Abstract excerpt

BACKGROUND: The Werner protein (WRN), defective in the premature aging disorder Werner syndrome, participates in a number of DNA metabolic processes, and we have been interested in the possible regulation of its function in DNA repair by post-translational modifications. Acetylation mediated by histone acetyltransferases is of key interest because of its potential importance in aging, DNA repair and...

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PMID: 18398454
DOI: 10.1371/journal.pone.0001918

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