Article
Listeria monocytogenes PerR mutants display a small-colony phenotype, increased sensitivity to hydrogen peroxide, and significantly reduced murine virulence.
Applied and environmental microbiology - 1 Dec 2005
Rea Rosemarie, Hill Colin, Gahan Cormac G M
Abstract excerpt
Deletion of perR in Listeria monocytogenes results in a small-colony phenotype (DeltaperRsm) that is slow growing and exhibits increased sensitivity to H2O2. At a relatively high frequency, large-colony variants (DeltaperRlg) arise, which are more resistant to H2O2 than the wild-type and ultimately dominate the culture. Transcriptional analysis revealed that the kat gene (catalase) is up-regulated in both types...
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