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Article

Intracellular multiplication and virulence of Shigella flexneri auxotrophic mutants.

Infection and immunity - 1 Feb 1998

Cersini A, Salvia A M, Bernardini M L

Abstract excerpt

We have constructed and analyzed a group of Shigella flexneri 5 auxotrophic mutants. The wild-type strain M90T was mutagenized in genes encoding enzymes involved in the synthesis of (i) aromatic amino acids, (ii) nucleotides, and (iii) diaminopimelic acid. In this way, strains with single (aroB, aroC, aroD, purE, thyA, and dapB) and double (purE aroB, purE aroC, purE aroD, purE thyA) mutations were obtained....

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Identifiers

PMID: 9453608
DOI: 10.1128/IAI.66.2.549-557.1998
PMCID: PMC107940

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