Intracellular multiplication and virulence of Shigella flexneri auxotrophic mutants.

doi:10.1128/IAI.66.2.549-557.1998

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Article

Intracellular multiplication and virulence of Shigella flexneri auxotrophic mutants.

Infection and immunity - 1 Feb 1998

Cersini A, Salvia A M, Bernardini M L

Abstract excerpt

We have constructed and analyzed a group of Shigella flexneri 5 auxotrophic mutants. The wild-type strain M90T was mutagenized in genes encoding enzymes involved in the synthesis of (i) aromatic amino acids, (ii) nucleotides, and (iii) diaminopimelic acid. In this way, strains with single (aroB,...

Topics

Adenine
Cefotaxime
HeLa Cells
Humans
Mutation
Phenotype
Shigella flexneri
Thymine
Virulence

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