Article
Aromatic compound-dependent Brucella suis is attenuated in both cultured cells and mouse models.
Infection and immunity - 1 Jan 2001
Foulongne V, Walravens K, Bourg G, Boschiroli M L, Godfroid J, Ramuz M, O'Callaghan D
Abstract excerpt
The aroC gene of the facultative intracellular pathogen Brucella suis was cloned and sequenced. The cloned aroC gene complements Escherichia coli and Salmonella enterica serovar Typhimurium aroC mutants. A B. suis aroC mutant was found to be unable to grow in a defined medium without aromatic compounds. The mutant was highly attenuated in tissue culture (THP1 macrophages and HeLa cells) and murine virulence models.
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