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Article

Analysis of CHEK2 gene for ovarian cancer susceptibility.

Gynecologic oncology - 1 Oct 2004

Baysal Bora E, DeLoia Julie A, Willett-Brozick Joan E, Goodman Marc T, Brady Mark F, Modugno Francesmary, Lynch Henry T, Conley Yvette P, Watson Patrice, Gallion Holly H

Abstract excerpt

OBJECTIVES: A deletion variant in the CHEK2 gene (del1100C) has been implicated as a low-penetrance risk factor for breast cancer. We sought to determine contribution of CHEK2 mutations to the etiology of ovarian cancer (OvCa). METHODS: We used cases ascertained from the United States through Gynecologic Oncology Group (GOG) protocols 172, 182, and 144, the University of Hawaii Cancer Research Center, and...

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Source

Identifiers

PMID: 15385111
DOI: 10.1016/j.ygyno.2004.07.015

Genes

CHEK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of CHEK2 gene for ovarian cancer susceptibility.PMID 15385111Read ↗

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations.Semantic proximity Read ↗

Identification of CHEK2 Germline Mutations in BRCA1/2- and PALB2-Negative Breast and Ovarian Cancer Patients.Semantic proximity Read ↗

Identification of a novel CHEK2 variant and assessment of its contribution to the risk of breast cancer in French Canadian women.Semantic proximity Read ↗

Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility.Semantic proximity Read ↗

Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts.Semantic proximity Read ↗

Linkage disequilibrium mapping of CHEK2: common variation and breast cancer risk.Semantic proximity Read ↗

Breast cancer risk is similar for CHEK2 founder and non-founder mutation carriers.Semantic proximity Read ↗

CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate.Semantic proximity Read ↗

Identification and analysis of CHEK2 germline mutations in Chinese BRCA1/2-negative breast cancer patients.Semantic proximity Read ↗

CHEK2 mutations and the risk of papillary thyroid cancer.Semantic proximity Read ↗

Irrelevance of CHEK2 variants to diagnosis of breast/ovarian cancer predisposition in Polish cohort.Semantic proximity Read ↗

Germline variant profiling of CHEK2 sequencing variants in breast cancer patients.Semantic proximity Read ↗

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