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Article

Linkage disequilibrium mapping of CHEK2: common variation and breast cancer risk.

PLoS medicine - 1 Jun 2006

Einarsdóttir Kristjana, Humphreys Keith, Bonnard Carine, Palmgren Juni, Iles Mark M, Sjölander Arvid, Li Yuqing, Chia Kee Seng, Liu Edison T, Hall Per, Liu Jianjun, Wedrén Sara

Abstract excerpt

BACKGROUND: Checkpoint kinase 2 (CHEK2) averts cancer development by promoting cell cycle arrest and activating DNA repair in genetically damaged cells. Previous investigation has established a role for the CHEK2 gene in breast cancer aetiology, but studies have largely been limited to the rare 1100delC mutation. Whether common polymorphisms in this gene influence breast cancer risk remains unknown. In this...

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Identifiers

PMID: 16671833
DOI: 10.1371/journal.pmed.0030168
PMCID: PMC1457009

Genes

CHEK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Linkage disequilibrium mapping of CHEK2: common variation and breast cancer risk.PMID 16671833Read ↗

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The CHEK2*1100delC allelic variant and risk of breast cancer: screening results from the Breast Cancer Family Registry.Semantic proximity Read ↗

Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility.Semantic proximity Read ↗

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Frequency of CHEK2 mutations in a population based, case-control study of breast cancer in young women.Semantic proximity Read ↗

The CHEK2 gene and inherited breast cancer susceptibility.Semantic proximity Read ↗

A search for modifying genetic factors in CHEK2:c.1100delC breast cancer patients.Semantic proximity Read ↗

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