Article
Role for PP2A in ARF signaling to p53.
Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 2004
Moule Madeleine G, Collins Crista H, McCormick Frank, Fried Mike
Abstract excerpt
Activation of the ARF-p53 tumor suppressor pathway is one of the cell's major defense mechanisms against cancer induced by oncogenes. The ARF-p53 pathway is dysfunctional in a high proportion of human cancers. The regulation of the ARF-p53 signaling pathway has not yet been well characterized. In this study polyoma virus (Py) is used as a tool to better define the ARF-p53 signaling pathway. Py middle T-antigen...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Polyomavirus Transforming
- Cell Transformation, Viral
- DNA Damage
- Embryo, Mammalian
- Fibroblasts
- Fluorescent Antibody Technique, Direct
- Mutation
- Phosphoprotein Phosphatases
- Polyomavirus
- Protein Structure, Tertiary
- Rats
- Signal Transduction
- Transfection
- Tumor Suppressor Protein p14ARF
- Tumor Suppressor Protein p53
- Up-Regulation