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Article

Role for PP2A in ARF signaling to p53.

Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 2004

Moule Madeleine G, Collins Crista H, McCormick Frank, Fried Mike

Abstract excerpt

Activation of the ARF-p53 tumor suppressor pathway is one of the cell's major defense mechanisms against cancer induced by oncogenes. The ARF-p53 pathway is dysfunctional in a high proportion of human cancers. The regulation of the ARF-p53 signaling pathway has not yet been well characterized. In this study polyoma virus (Py) is used as a tool to better define the ARF-p53 signaling pathway. Py middle T-antigen...

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Share to Antigens, Polyomavirus Transforming
Share to Cell Transformation, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Fluorescent Antibody Technique, Direct

Share to Phosphoprotein Phosphatases

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Share to Tumor Suppressor Protein p14ARF

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Source

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Identifiers

PMID: 15383668
DOI: 10.1073/pnas.0405533101
PMCID: PMC521121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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