Article
Chemical basis for the affinity maturation of a camel single domain antibody.
The Journal of biological chemistry - 17 Dec 2004
De Genst Erwin, Handelberg Fabian, Van Meirhaeghe Annemieke, Vynck Samuel, Loris Remy, Wyns Lode, Muyldermans Serge
Abstract excerpt
Affinity maturation of classic antibodies supposedly proceeds through the pre-organization of the reactive germ line conformational isomer. It is less evident to foresee how this can be accomplished by camelid heavy-chain antibodies lacking light chains. Although these antibodies are subjected to somatic hypermutation, their antigen-binding fragment consists of a single domain with restricted flexibility in favor...
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