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Article

Single antibody domains as small recognition units: design and in vitro antigen selection of camelized, human VH domains with improved protein stability

1 Jan 1996

Abstract excerpt

Folding stabilities of camelized human antibody VH domains were studied through the determination of their melting points in thermodenaturation experiments. The melting point of a VH domain originating from a synthetic library of human VHs, which had been optimized for the use as small recognition units through the mimicking of camelid antibody heavy chains occurring naturally without light chain, was 56.6...

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PMID: 8862554
DOI: 10.1093/protein/9.6.531

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