Article

Conformational diversity of CDR region during affinity maturation determines the affinity and stability of Sars-Cov-1 VHH-72 nanobody

2020-12-09

Abstract excerpt

The affinity maturation of Sars-Cov-1 VHH-72 nanobody from its germline predecessor has been studied at the molecular level. The effect of somatic mutations accumulated during affinity maturation process on flexibility, stability and affinity of the germline and affinity matured nanobody was studied. Affinity maturation results in loss of local flexibility in CDR of H3 and this resulted in a gain of affinity towar...

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Literature Corpus work: b1f6e788-d6ee-5a45-b470-3b67bdd9a985
DOI: 10.1101/2020.12.08.416164

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