Article
Potential Minor Haplotypes of CYP2D6 in the Japanese Population.
Drug metabolism letters - 17 Nov 2017
Masuda Masatoshi, Fujiwara Tsutomu, Matsunaga Masayuki, Matsumaru Takehisa
Abstract excerpt
BACKGROUND: CYP2D6 is one of the most significant polymorphic genes of drugmetabolizing enzymes due to its association with different metabolic activities and the pharmacokinetics of CYP2D6 substrates. OBJECTIVE: The objective of this study was to explore for a novel haplotype of CYP2D6 in the Japanese population by using a large database of previous clinical studies. METHODS: We analyzed CYP2D6 genotype data...
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